User Guide
About ProBioQuest:
• A database-advanced search engine platform for researchers, healthcare professionals, probiotics developers and the public to query on probiotics and health conditions
• You could enter a keyword for enquiry to obtain a scientific overview and unique insights of relevant key concepts
• You could also explore by selecting from word cloud at Home page
• Further information about bacteria features, marketed probiotics, drugs, and its public awareness over time are searchable by linking to external sources
• ProBioQuest automatically and regularly collects literatures, clinical trials, and US patents from PubMed.gov, ClinicalTrials.gov and PatentsView
Search and Interface :
• At Home page, you may select from a word cloud of the most frequent keywords from all articles of the database
• Alternatively, you may input keyword for query in the search bar. Suggestions based on our keyword bank will show up for easy selection
• Each query, by default, searches all sources in ProBioQuest database and returns preview of articles with the most relevant listed on top in Search Result tab
• In the preview, you can find title, relevant sentence(s), source, and publication date
• For clinical trials, you may click Show Details for identifier, study type and location
• You will be directed to the article source by a simple click on the interested title
• In Keyword Bank tab, you can find our novel feature for related key concept discovery on your interested topic. This tab shows relevant keywords in descending order of number of articles they co-exist
• Keywords are presented in categories
• These keywords can also be found in the scrollbar on the left
• Second keywords can be appended to the search, individually searched, and linked out
• All external links are directed to search result of the same keyword(s) used in ProBioQuest for your convenience
• Search results in ProBioQuest can be downloaded in Export tab
• The search function and interface are illustrated by examples below
• A video guide is available at the end of the page
Search Demonstration :
Query about disease or health conditions:
• You can search by disease, disorder, and symptoms for overall concept of the health condition and relevant discomfort, and existing probiotics for treatment. Below you can find a demonstration using autism as example (Fig. 2).
• Example questions: “Is there any conditions commonly experienced by Autism patients?”, “Could probiotics relieve autism?”
• Search of “Autism” returns 2252 articles (Fig. 3). You may obtain clearer understanding towards autism by reading the articles.
• Keyword Bank tab gives you overall concept that autism is commonly discussed with other conditions like anxiety, schizophrenia, dysbiosis and hyperactivity (Fig. 4).
• If you are interested in finding probiotics beneficial to autism patients, you may check keyword category Bacteria / Probiotics. Potential probiotics target is rapidly narrowed down to 8 species. Top species found is Lactobacillus plantarum. It can be linked out for its related taxonomy and strain information like culture conditions (Fig. 5)
• By appending Lactobacillus plantarum to the search, a specific strain and clinical trial on the strain show up (Fig. 6). Its potential in relieving autism can be further evaluated. You can link out to search for additional information, such as related drugs on Drugs.com, on the left scroll bar (Fig. 7)
Query about probiotics:
• You can search by bacteria, probiotics, microbiome for potential health impact, related taxonomy, and strain information like culture conditions. Below you can find a demonstration using Bifidobacterium lactis as example (Fig. 8).
• Example questions: “Is Bifidobacterium lactis well established for safe consumption?”, “What health conditions and bacteria are closely related to Bifidobacterium lactis?”
• Search of “Bifidobacterium lactis” returns 424 articles (Fig. 9). You may obtain clearer understanding towards Bifidobacterium lactis by reading the articles. For safety issue, you can select Clinical Trials from search bar.
• Keyword Bank tab gives you overall concept that Bifidobacterium lactis is commonly discussed with health conditions like inflammation, diarrhea, irritable bowel syndrome and constipation (Fig. 10)
• If you are interested in developing probiotics product, you can find from category Bacteria / Probiotics in Keyword Bank that Lactobacillus acidophilus is the most co-discussed probiotics with Bifidobacterium lactis (Fig. 11).
• You can append Lactobacillus acidophilus to the search (Fig. 12) or link out for its related taxonomy and strain information like culture conditions on BacDive (Fig. 13).
• You can export search results in Export tab or link out for additional information on Drugs.com, Amazon or more, on the left scroll bar (Fig. 14).
For video guide, please visit here.
Sponsored by:Probiolife limited
Copyright:kwanlab , CUHK