Professor Hoi Shan KWAN, PhD, BBS, JP


Office Address:        Room 288, Science Centre

Telephone No.:        39436251

Fax No:                      26035646

E-mail Address:

Webpage (URL):



Doctor of Philosophy University of California, Davis 1978-1982
 (Thesis supervisor: E.L. Barrett)
Master of Philosophy Chinese University of Hong Kong 1975-1978
(Thesis supervisor: S.T. Chang)
Postgraduate Diploma in Microbiology & Biotechnology Osaka & Kyoto Univ., Japan 1976-1977
Bachelor of Science Chinese University of Hong Kong 1971-1975


Dean of General Education                                   United College, CUHK              2012-16

Associate Head                                                         United College, CUHK              2012-16

Dean of Science Chinese Univ. of Hong Kong 2006-09
Acting Dean of Science Chinese Univ. of Hong Kong 2005-06
Associate Dean of Science Chinese Univ. of Hong Kong 2003-05
Professor in Biology/School of Life Sciences Chinese Univ. of Hong Kong 1997-Present
Honorary Professor in Chinese Medicine Chinese Univ. of Hong Kong 1999-Present
Visiting Professor in Microbiology Nankai University 1998-Present
Associate Professor in Biology Chinese Univ. of Hong Kong 1996-97
Senior Lecturer in Biology Chinese Univ. of Hong Kong 1994-96
Lecturer in Biology Chinese Univ. of Hong Kong 1984-93
Visiting Assistant Professor in Microbiology & Molecular Genetics Harvard Medical School 1992-93
Postdoctoral Research Bacteriologist Univ. of California, Davis 1983-84
Postdoctoral Research Microbiologist Univ. of California, Davis 1982
Associate in Food Science & Technology Univ. of California, Davis 1979-81
Research Assistant, Dept of Food Science & Technology Univ. of California, Davis 1979-82


Member, Genetics Society of America (2007-present)

Member, American Society for Microbiology (1982-present)

Member, American Association for Advancement of Science (1982-present)

Chief Expert Panel Leader, Hong Kong Food Science and Technology Association (1995-present)

Consultant, International Food Safety Association (2010-present)

Member, World Society of Mushroom Biology and Mushroom Products (1993-1995)

Member, Hong Kong Society of Microbiology (1984-1995)


 1. Molecular genetic analysis and genomics of edible mushroom Lentinula edodes for strain typing, genetic maps and breeding programmes.
 2. Molecular cloning, analysis and utilization of cellulase, glucoamylase and ligninase genes from mushrooms.
 3. Genomics and functional genomics of Shiitake mushroom Lentinula edodes and the model mushroom Coprinopsis cinerea
 4. Genome sequencing and database of pathogenic bacteria
 5. Hong Kong Food composition database
 6. DNA authentication and marker sequence database of dried seafoods and tonic food stuff
 7. Research and development of traditional Chinese medicine-based pharmaceuticals and nutraceuticals
 8. Biocontrol of Brown Root Rot diseases caused by the fungus Phellinus noxious
 9. Metagenomics of natural ecosystems and human microbiota
 10. Genetic analysis of the probiotic Bifidobacterium beta-glucan utilization pathways
 11. Single cell genome sequencing

 I have been very active in research. I have been persistently introducing state-of-the-art molecular technologies and instruments to the Science Faculty and CUHK since my joining the University. I consider myself one of the main promoters of molecular biology in CUHK.


My research interests are diverse and always incorporate the most recent and important research development. For example,

  1. I have obtained, as principle investigator or co-investigator, over HK$132 million of external competitive research funding (HK$54m as PI and HK$78m as Co-I).
  2. My group was the first group in Hong Kong to perform polymerase chain reaction (1988), to sequence DNA manually (1986) and with automated sequencer (1997), to authenticate Chinese medicinal materials with molecular tools (1991),  to sequence genomes with the Next Generation Sequencer (2008), and to use NGS to characterize microbiota form the environment and human body.
  3. I acquired the first genome sequencer and set up the first genome sequencing service in Hong Kong.
  4. I have ample experience in collaborating with faculty members in many disciplines.  My collaborators include people in our university, from Biochemistry, Biology, Chemistry, Chinese Medicine, Mathematics, Statistics, and Medicine.
  5. My laboratory is the world-leading laboratory in Shiitake mushroom Lentinula edodes genetics and genomics. I am also part of a consortium working on genomics of the model mushroom Coprinopsis cinerea.
  6. I am also part of a consortium working on pathogen genomics, especially foodborne pathogens and tuberculosis bacteria.
  7. I have been a core member of the consortium on functional genomics of C. cinerea, supported by Community Science Program 2012 of Joint Genome Institute, Department of Energy, USA.
  8. I have been a team member in many important projects including the Area of Excellence “Plant and Fungal Biotechnology”.
  9. I have led several substantial research projects including “Construction of Food Composition Database for Nutritional Labelling”, a project funded with HK$17.7 million by the Jockey Club Charity Funds.  The project aims to benefit many small and medium enterprises in the Hong Kong food industry. Another project is “First-Stage Development of a Comprehensive Genome Sequence Database for the Identification of Foodborne Pathogens in Hong Kong”, a project supported with HK$6.1 million by the Research Fund for Control of Infectious Diseases, Food and Health Bureau.  I have also leading the food authentication effort in Hong Kong with a HK$3 million fund from Innovation and Technology Commission: “First-stage development of platform for authentication of dried seafood and tonic food products”.  In the past years, I have led the Science Faculty to collaborate with other faculties within CUHK, with other universities in Hong Kong and in mainland China, as well as government departments in Hong Kong. I understand and recognize good scientific research and at the same time realize the demands of the society on applied scientific research. Especially worth mentioning is my laboratory has developed into a powerhouse of bioinformatics. We are now capable of performing world class analysis on genomics and metagenomics.

These research experiences allow me to

  1. understand and appreciate good research in many science disciplines,
  2. promote collaborative research among faculty members from different disciplines to target on more substantial projects synergistically,
  3. obtain and effectively manage funds to support the research endeavour of the Science Faculty, and
  4. recognize the importance of research excellence in teaching and learning at undergraduate and postgraduate levels.

I have been very active in research. My research concentrates on the application of molecular biological technology in the studies of basic and applied biological problems.  For all my years in CUHK, I have been the major source of molecular technology in the Biology Department, the Science Faculty and CUHK as a whole.  Since 1993, the Biology Department has placed great emphasis in molecular biology and biotechnology leading to our success in being identified as an area of excellence in “Plant and Fungal Biotechnology”.  I cannot over-emphasize that I have been contributing to the development of CUHK in this direction persistently and consistently for a long time.  I have applied, as principal investigator, for RGC Cooperate Research Fund for equipment to set up the Centre for Single Cell Genome Sequencing.



DNA-DNA hybridization on solid supports for the authentication of traditional Chinese medicinal plants (principal investigator) (US patent #7297490, 2008)

Knowledge transfer projects

Project Title Granting agency Commence Complete


Virtual Dietician at 1 touch – Develop an

Apple application on the 1stHong Kong commonly

used food and ingredient database for portable
handheld users

Knowledge Transfer Project Fund 1-Mar-11 28-Feb-12


Construction of the First Food Safety Information Database for Hong Kong and Greater China Knowledge Transfer Project Fund 1-Jan-12 30-Jun-13


Formation of free fatty acids, trans fatty acids and acrylamide in edible oils during different cooking process Knowledge Transfer Project Fund (INSEED) 15-Feb-13 14-Feb-14


Healthy eating and active living for the elderly Knowledge Transfer Project Fund (ICON) 1-Mar-13 30-Apr-14


A Healthy Eating and Active Living Promotion Program for Ethnic Minority Children in Hong Kong Knowledge Transfer Project Fund (ICON) 15-Feb-14 14-Apr-15







Invited presentations and lectures at conferences, scholarly meeting, workshops, symposia, exhibitions, or other public forums (Total: 69)

1. Probiotics, Prebiotics & Health, 12th Nutrition & Health Symposium, Centre for Nutritional Studies, CUHK (21 Nov 2015)

Gut Microbiome, Probiotics, Prebiotics, Synbiotics and Health

2. Food Safety Seminar, International Food Safety Association (7 Nov 2015)

Gut Microbiome, Probiotics, and Food Safety

3. Vitafoods Asia 2015 (3 September 2015)

Synbiotics: Probiotics, Prebiotics, and Functional foods

4. Second Workshop on Advanced Methods in Food Microbiology and Chemistry, City University of Hong Kong (12 May 2015)

Genome Sequencing for Foodborne Pathogenic Bacteria Analysis

5. Food Safety Seminar, International Food Safety Association (7 May 2015)

The Microbiome

6. SCEIFD Meeting (23 April 2015 )

Outbreak Investigation with Bacterial Genomics

7. Seminar, International Food Safety Association (13 March 2015)

Microbiome and Me: We Are As One

8. Annual General Meeting , International Food Safety Association (29 November 2014)

Food Incidents: Scandals & Outbreaks

9. Health Research Symposium 2014 (15 November 2014)

First-Stage Development of A Comprehensive Genome Sequence Database for the Identification of Foodborne Pathogens in Hong Kong

10. Testing and Certification Conference 2014 (12 November 2014)

Testing and Certification for Food Safety in Hong Kong

11. Food Safety Seminar: Food Trap and Opportunity, College of International Education, HKBU, HK (6 November 2014)

Food Incidents: Scandals & Outbreaks

12. Summit on Child Health and the Environment 2014 (12 October 2014)

Food Safety, Food Authentication, and Children’s Health

13. PEF BIO International Convention & Study Mission 2014- Trip Report and Sharing Session (8 October 2014)

Learning from peers: knowledge transfer and biotechnology trends

14. The 9th International Mycological Congress, Bangkok, Thailand (7 August 2014)

Mushroomics: Omics of Lentinula edodes and Coprinopsis cinerea

15. 2014年中國调味品协会调味酱专业委员会年会 (14 May 2014)


16. Fungal Genomics Training Workshop/Symposium, Kunming (11 May 2014)

Mushroomics: Comparative genomics of Xiang-gu Lentinula edodes and model mushroom Coprinopsis cinerea

17. 食品安全系统化战略论坛 Food Safety systematic strategy forum, United International College, Zhuhai (19 April 2014)

Food Safety Management System in Hong Kong 香港食品安全監管機制介紹

18. Lectures at Huazhong Agricultural University, Wuhan (30 November 2013)

From Shiitake genomics to comparative mushroom genomics: Mushroomics

19. Lectures at Huazhong Agricultural University, Wuhan (30 November 2013)

How to write a scientific paper

20. 食品安全檢測技術趨勢研討會, Hong Kong Productivity Council(22 November 2013)

Application of Molecular Biotechnology in Food Safety and authentication


21. Lecture at Chengdu Green Center (4 November 2013)


Food Databases FRC CUHK

22. Lecture at Chengdu Green Center (4 November 2013)

Food Research Centre, The Chinese University of Hong Kong

香港中文大學 食品研究中心

23. 粵港澳三地食品安全專家講座, Macau Centre for Food Safety (23 Sept 2013)


24. Half-day Symposium on Cancer Prevention and Rehabilitation, HK (8 Sept 2013)

Microbiome, Probiotics and Cancer

25. The 16th International Exhibition of Food & Drink, Hotel, Restaurant & Food Service Equipment, Supplies & Services, HK (9 May 2013)

Greater China food safety information database

26. The Sixth China Beijing International Food safety Forum, Beijing, China (1 April 2013)

Greater China food safety information database

27. International Food Safety Association Food Safety Seminar, HK (9 March 2013)


28. The 8th Lau Oi Wah Memorial Science Lecture Series, CUHK, HK, (17 November 2012)

Decoding Human Genome

29. 食品安全考察學習培訓班, 香港 (13 July 2012)


30. 新高中通識教育科知識增益研討會:香港食物安全問題, 香港 (31 May 2012)


31. Invited lectures, College of International Education, HKBU, HK (9 March and16 March, 2012)

Authentication of dried seafood and tonic foodstuff

32. Symposium on Food Identification and Authentication, HK (17 January, 2012)

DNA marker sequence database for authentication of dried seafood and tonic foodstuff in Hong Kong

33. Seminar and Networking Dinner Organized by the Innovation and Technology Commission (ITC), Accreditation Advisory Board(AAB) and the Hong Kong Council for Testing and Certification(HKCTC), HK (8 December, 2011)

Keynote speech: Work of Accreditation Advisory Board (AAB)

34. College Bi-weekly Assembly, New Asia College, The Chinese University of Hong Kong, HK (25 November, 2011)

Mysteries in Food Safety: Invisible Enemies

35. Roche Applied Science User Meeting, HK (3 November, 2011)

Roche 454 Sequencing in Mushroom Genomics

36. The 7th International Conference on Mushroom Biology and Mushroom Products, Arcachon, France (4-7 October 2011)

Genome sequence, functional genomics & genetic linkage analysis of Shiitake mushroom Lentinula edodes

37. 海峡两岸第十届菌物学暨第三届食药用菌学术研讨会, Wuhan, China (15-18 July, 2011)


38. Lecture at Huazhong University of Science and Technology, Wuhan, China (1 December, 2010)

Bioinformatics platform for microbial genomic analysis

39. Lecture at Huazhong University of Science and Technology, Wuhan, China (1 December, 2010)

Microbial genomics analysis

40. Lecture at Huazhong University of Science and Technology, Wuhan, China (1 December, 2010)

The lignocellulolytic system of Shiitake mushroom

41. 全國食用菌基因組與基因工程專題學術研討會, Wuhan, China (13-14 November, 2010)

Identification and cloning of fruiting-related genes in Shiitake mushroom Lentinula edodes.

42. 全國食用菌基因組與基因工程專題學術研討會, Wuhan, China (13-14 November, 2010)

Genome sequence analysis of Shiitake mushroom Lentinula edodes

43. 第九届全国食用菌学术研讨会, Shanghai, China (14-18 October, 2010)


44. The 9th International Mycological Congress: The Biology of Fungi, Edinburgh, UK (1-6 August, 2010)

Genomic analysis and fruiting body development of Shiitake mushroom Lentinula edodes.

45. China’s Fungal Genome Initiative Symposium, Shanghai, PRC China (20-22 September, 2009)

Genomics and functional genomics of Shiitake mushroom Lentinula edodes.

46. Advances in BioChemical Engineering Sciences Sympoisum, China (5 August 2009)

Mushroom Genomics and Functional Genomics

47. The World Nutrition, Health & Disease Conference, Singapore (21 July, 2009)

Current Nutritional Situation In Asia Versus The West—two examples—Nutrition Labelling and Food Consumption Survey

48. The 25th Fungal Genetics Conference, California, USA. (17-22 March, 2009)

Towards a better understanding of fruiting body development in basidiomycetous mushroom.

49. China International Food Safety & Quality Conference, China (24-25 September, 2008) Chairman of the Food Quality and Nutrition Hot Topics Session

50. China International Food Safety & Quality Conference, China (24-25 September, 2008)

Construction of Food Composition Database for Nutrition Labeling in Hong Kong

51. 香港中文大學代表團訪問上海交通大學及復旦大學, China (17-19 July 2008)


52. Environment, Health and Harmony: An Interdisciplinary Student Leadership Conference, HK (14 – 17 July 2008)

Food Safety and Risk Analysis in Hong Kong

53. 3rd Cross-Strait Symposium on Food and Biotechnology 2008, HK (15-16 May 2008)


54. Food Safety Workshop for Media Workers, HK (28 April 2008)


55. 國家食品葯品督管局交流訪問團, HK (19 December 2007)

香港的食物安全: 政府的角色

56. HK Associate for Testing Inspection and Certification Ltd, HK (12 December 2007)

Food Safety in Hong Kong: Role of Government

57. Hong Kong Quality Assurance Agency Symposium: Social Challenges and Business Opportunities in Food Health and Safety, HK (20 November 2007)

How do Customers Benefit from Food Labelling System

58. 8th Asia/Oceania Regional Congress of Gerontology and Geriatrics, Beijing, PRC (23-25 October 2007)

Nutrition and chronic disease epidemiological and preventive strategy of old population: Maintaining health of intestinal microbiota, maintaining health – Intestinal bacteria and ageing

59. 24th Fungal Genetics Conference, Pacific Grove, CA, USA (20-25 March 2007)

Transcriptome analysis of shiitake mushroom Lentinula edodes development using multiple methods

60. International Symposium on Food Safety, Hong Kong (12-13 January, 2007) Moderator for Risk Management Session

61. 8th International Mycological Congress, Cairns, Australia (20-25 August 2006)

Differential Display, cDNA Microarray, Expressed Sequence Tags and Serial Analysis of Gene Expression (SAGE) reveal Gene Expression Profiles of Shiitake Mushroom Lentinula edodes Developmen t

62. The 50th Anniversary Annual Meeting for MSJ, Chiba, Japan (June 3-4, 2006)

Identification by Long Serial Analysis of Gene Expression of genes differentially expressed in sporulating fruiting bodies of Shiitake Mushroom Lentinula edodes

63. 8th European Conference on Fungal Genetics, Vienna, Austria (8-11 April 2006)

Expressed Genes during Development of Shiitake Mushroom Lentinula edodes Examined by Serial Analysis of Gene Expression

64. Mycological Society of America and Mycological Society of Japan Joint Meeting 2005, Hilo, Hawaii, USA. (July 30-August 5, 2005)

Gene Expression Profiles of Shiitake Mushroom Lentinula edodes Revealed by Differential Display, cDNA Microarray and Serial Analysis of Gene Expression (SAGE)

65. Symposium, Developmental Genomics and Bioinformatics, Faculty of Medicine, CUHK. (2005)

Gene expression profiles of shiitake mushroom Lentinula edodes revealed by Differential Display, cDNA Microarray and Serial Analysis of Gene Expression (SAGE)

66. Asia-Pacific Mycological Conference on Biodiversity and Biotechnology, Hua Hin, Thailand. (1998)

Application of Molecular Biology in studies of cultivated mushrooms.

67. Workshop on Genomic Fingerprinting, Centro de Reuniones Internacionales Sorbre Biologia, Instituto Juan March de Estudios e Investigaciones, Madrid, Spain. (1993)

Application of Arbitrarily-primed Polymerase Chain Reaction genomic fingerprinting in molecular studies of Basidiomycetous Fungi

68. The International Symposium on Recent Topics in Genetics, Physiology and Technology of the Basidiomycetes, Chiba, Japan (1992)

Application of Arbitrarily-primed Polymerase Chain Reaction in molecular studies of mushroom

69. Applications of fungi in biotechnology”, First Symposium of Mycology in Asia (MIA I), Bangkok, Thailand (1991)

Molecular strain typing of Lentinula edodes





World Society of Mushroom Biology and Mushroom Products Treasurer 1993-95
Hong Kong Society of Microbiology Secretary 1985-89


Reviewer to journals:
BMC Microbiology
Canadian Journal of Microbiology
Biomolecular Engineering
Molecular Ecology
FEMS Microbiology Letters
Chinese Medicine
Mycological Research
Plos One
Applied and Environmental Microbiology
Chinese Science Bulletin
Eukaryotic Cell
Journal of Agricultural and Food Chemistry
Current Genetics
Applied Microbiology and Biotechnology
Critical Reviews of Microbiology
Fungal Genetics and Biology
BMC Bioinformatics
Fungal Biology
BMC Genomics
Journal of Basic Microbiology
Genomics, Proteomics & Bioinformatics



Graduated PhD students (Total: 16)

Graduated MPhil students (Total: 30)


Current PhD Students (Total: 6)

Current MPhil Students (Total: 2)


Current Student Supervised (9):

  1. Chen Shanquan (PhD)
  2. Chang Jinhui (PhD)
  3. Cheung Man Kit (PhD)
  4. Keung Hoi Yee (PhD)
  5. Tsang Sze Wing (PhD)
  6. Li Tsz Kai (Mphil)
  7. Zhong Yiyi (PhD)
  8. Regent Lam (Mphil)



The highest degree and current/last known position of the student are included in parenthesis

Master of Philosophy Theses :  30 (22 obtained PhD)


1. Xing Lei


Transcription Profiling of Pectinase Genes in Lentinula edodes and their Heterologous Expression in Pichia pastoris (Research Assistant, CUHK)
2. Luo Xiao


Sequence Analysis and Transcriptional Profiling of Ligninolytic Genes in Lentinula edodes (Research Assistant, CUHK)
3. Wong Man Chun


Genome Survey Sequencing and Molecular Markers Development of Shiitake Mushroom Lentinula edodes (Project Coordinator, CUHK)
4. Cui Ju


Proteomic Study on Ovarian Maturation of the Shrimp Metapenaeus ensis (Co-supervised with KH Chu) (PhD Candidate, HKU)
5. Cheng Chi Keung


Genomic and gene expression studies of Coprinopsis cinerea by 5’ Serial Analysis of Gene Expression (SAGE) (PhD, CUHK; Research Scientist, Medical Testing Laboratory)
6. Sham Lok To


Promoter analysis and transcriptional factors identification in Lentinula edodes (PhD, Univ of Indiana at Bloomington; Post-doctoral fellow, Harvard Medical School)
7. Lee Ming Tsung


Endocytic pathway in Shiitake mushroom Lentinula edodes development: role of Le.Rab7 and interacting proteins (PhD, University of Cincinnati; Research Scientist, Kinex Pharmaceuticals (HK) Limited, HK)
8. Hui Cheung


Transformation studies of signal transduction genes of Shiitake mushroom Lentinula edodes (Mushroom and food business owner)
9. Yip Pui Ying, Anna


Molecular Authentication of Selected Traditional Chinese Medicinal Plants (Executive Officer, CUHK)
10. Chau Hoi Yee, Betty


Differentially Expressed Genes during Leave Development of rice (PhD, HKU; Research Associate, Univ of Philadephia, USA)
11. Wong Wing Lei, Queenie


Molecular Cloning and Characterization of a two-component histidine kinase of Shiitake Mushroom Lentinula edodes (PhD, CUHK; Senior Instructor, University of Macao, Macao)
12. Shih Sheung Mei,  Rita


Identification and Characterization of Genes Differentially Expressed in Dikaryotic Mycelium of Shiitake Mushroom Lentinula edodes by cDNA Microarray Hybridization (PhD, Univ of Maryland; Senior Scientist, Thermos-Fisher, USA)
13. Tjia Wai Mui, Joanna


Molecular Analysis of Stress Responses of Shiitake Mushroom Lentinula edodes (PhD, University of Calgary; Post-doctoral Fellow, University of Calgary)
14. Chum Wing Yan, Winnie


Serial Analysis of Gene Expression during Fruit Body Development of Shiitake Mushroom Lentinula edodes (PhD, CUHK; Chemist, Government Laboratory, Hong Kong SAR)
15. Ng Tak Pan


Elucidation of Gene Expression Profiles during Fruit Body Development of Shiitake Mushroom Lentinula edodes using Expressed Sequence Tags (PhD, HKU; Research Assistant Professor, HKU)
16. Chu Kin Kan


Genetic mapping of sequence tag sites, expressed sequence tags and agronomic traits of Shiitake Mushroom Lentinula edodes L54  (Assistant Lecturer, CUHK)
17. Leung Sze Wan, Grace


Identification and characterization of genes differentially expressed during fruit body development of Shiitake ushroom (Xianggu) Lentinula edodes  (PhD, Tufts Univ. Medical School, USA; Associate, Harvard Univ, USA)
18. Ng Wai Leung


Molecular analysis of the anaerobic-inducible gene nrdD from Salmonella typhimurium  (PhD, Univ. of Indiana at Bloomington, USA; Assistant Professor Sackler School of Graduate Biomedical Sciences, Tufts University, USA)
19. Xie Weijun


Differentially expressed genes during fruit body development of Shiang-gu mushroom, Lentinula edodes (PhD, Univ. of Texas at Austin, USA)
20. Cheung Ka Shing


Molecular cloning of ushroom gene from Volvariella volvacea (Conservation Officer, HKFACD)
21. Lai Siu Hong


Arbitrarily primed polymerase chain reaction and electrophoretic karyotype analyses  of Shiitake mushroom (Lentinula edodes) (Senior Graduate Master of a Hong Kong high school)
22. Tam Fung Ping


Molecular analysis of the promoter of anaerobic-inducible gene arcA of Salmonella typhimurium (PhD, Brendeis Univ, USA; Scientist of a biotechnology company in Boston)
23. Tam Yan Kit


Enzyme polymorphism and phylogenetic relationship of the shrimps Penaeus and Metapenaeus, from South China (Co-supervised with Dr. K.H. Chu)  (PhD, Univ. of Maine; Post-doctoral fellow, Univ of Maine, USA; Senior Graduate Master, HK)
24. Cheung Man Wai


Molecular analysis of anaerobiosis-inducible promoter of arcA of Salmonella typhimurium (PhD, HKUST; Scientific Officer, CUHK)
25. Leung Hon Chiu


Ethanol production by anaerobic fermentation in genetically manipulated enteric bacteria (PhD, Univ. of Texas, Houston Medical Center; Director, Proteomic Unit, Genome Centre of Singapore; Assistant Professor, Baylor College of Medicine, USA)
26. Pang Ka Ming


Cloning of chlC::Mud fusion of Salmonella typhimurium (PhD, Univ. of Connecticut; Research Scientist, City of Hope Medical Center, Los Angeles, CA,USA )
27. Chau Ching Man


Genes encoding enzymes for the conversion of acetyl-coA to fermentation end products (PhD, Northwestern Univ.; Research Assistant Professor, Program of Molecular Medicine, Univ of Massachusetts Medical School, Worcester, MA, USA)
28. So Kam Hing


Production and characterization of β-amylase from Bacillus  circulan (co-supervised with Dr. K.Y. Chan) (Product Specialist, Pharmacia, HK)
29. Chan Yuen Shan


Anaerobic regulatory mutations in Salmonella typhimurium  (PhD, CUHK; Medical Technologist, Medical School, CUHK)
30. Wong Kwong Kwok


Transcriptional regulation of pyruvate format lyase structural gene pfl in anaerobic metabolism of Salmonella typhimurium with pfl::Mud1-8 (Apr lac) operon fusions (PhD, CUHK; Professor, University of Texas MD Anderson Cancer Center, USA)

Doctor of Philosophy Theses:  16


1. Cheng Xuanjin


A ‘Developmental Hourglass’ and Putative MicroRNA-like Genes in the Mushroom, Coprinopsis cinerea (Research assistant, CUHK)
2. Li Lei


Database Construction and Computational analysis of Bacterial Small Regulatory RNAs.  (Post-doctoral fellow, Germany)
3. Lee Yung Yung, Crystal


Identification of fruiting-related genes and the endocytic pathway of the basidiomycete, Coprinopsis cinerea (Executive Officer, CUHK)
4. Wong Kin Sing


A post-genomic study of Lentinula edodes laccases: from basic sciences to potential applications and molecular engineering (Chemist, The Hong Kong Jockey Club, HK)
5. Cheng Chi Keung


Genome annotation and identification of blood invasion genetic determinants in Salmonella Typhimurium (Research Scientist, Medical Testing Laboratory)
6. Huang Qianli


Bioinformatic mining and analysis of genetic elements in genomes (Associate Professor, HeFei University of Technology, China)
7. Au Chun Hang


Genome Sequence of Shiitake Mushroom Lentinula edodes and Comparative Mushroom Genomics with Platform Construction (Associate Medical Technologist (Bioinformatics), Hong Kong Sanatorium & Hospital)
8. Kwok Sze Wai


The Lignocellulolytic System in Lentinula edodes (Research Scientist, Biotechnology company in Boston)
9. Chum Wing Yan, Winnie


Identification and characterization of differentially expressed genes in Shiitake ushroom (Xianggu) Lentinula edodes (Chemist, Government Laboratory, HK)
10. Szeto Ying Ying, Carol


Isolation and characterization of Le.MAPK and Le.Nik1 in Lentinula edodes related to development (Senior Scientist, HSK GeneTech Limited, HK)
11. Dong Biao


Gene Expression in the Leaves of Super Hybrid Rice and Identification of DNA Markers for Erect Flag Leaf (Co-supervised with Prod. SSM Sun) (Associate scientist and Manager of viral core facility, Sol Sherry Thrombosis Research Center, Temple University, Philadelphia)
12. Bian Xuelin


Elucidation of Gene Expression Profiles during Fruit Body Development of Shiitake Mushroom Lentinula edodes (Post-doctoral fellow, Purdue University)
13. Mak Chun Ying, Avis


Molecular analysis of Traditional Chinese Medicinal plants for authentication and standardization (Co-supervised with Prof. OW Lau) (Chemist, Government Laboratory, HK)
14. Jiang Qing Lan


Phylogenetic relationships and classification of Murines in Guangdong Province based on the analysis of karyotype and mitochondrial DNA sequence (Co-supervised with Prof. V.E.C. Ooi) (Post-doctoral fellow, University of Wisconsin)
15. Xu Hailau


Construction of a RAPD map and locating mating type markers of Shiitake mushroom Lentinula edodes. (Lecturer, Singapore Polytechnic)
16. Wong Kwong Kwok


Molecular cloning and characterization of anaerobiosis-inducible promoters from Escherichia coli and Salmonella Typhimurium   (Co-supervised with Dr. P.K. Wong) (Professor, University of Texas MD Anderson Cancer Center, USA)


Post-doctoral Fellow/Scientist trained:

  1. Dr. Eddie Dean
  2. Dr. Zhang Mingda
  3. Professor Chen Yuehua
  4. Professor Chau Chi Fai
  5. Dr. Xin Yeyun
  6. Professor Wong Ka Hing
  7. Dr. Bao Dapeng
  8. Dr. William Cheung Man Wai
  9. Dr. Patrick Law Tik Wan
  10. Dr. Tommy Au Chun Hang
  11. Dr. Cheryl Mak Sze Pui
  12. Dr. Wendy Fung Yin Wan
  13. Dr. Huang Qianli
  14. Dr. Wong Kin Sing
  15. Dr. Billy Cheng Chi Keung
  16. Dr. Liam Lee Ming Tsung
  17. Dr. Xiao Yang



Teaching (Other Contributions)

Concurrent Positions:
Dean Faculty of Science 2006-2009
Acting Dean Faculty of Science 2005-2006
Associate Dean Faculty of Science 2003-2005
Dean General Education, United College 2012-present
Associate Head United College 2012-present
Director Food and Nutritional Science Programme 1994-95; 96-97;98-99; 2003-2005
Director Molecular Biotechnology Programme 1999-2003
Director Research Laboratory of Food Science 1991-92; 97-present
Head Biology Graduate Division 1995-1999
Head Graduate Panel/Division of Life Sciences 2011-present
Acting Chairman Biology Department 1997-2010 (Occasional)
Dean of  Students United College, CUHK 1991-93
Associate Director Food and Nutritional Science Programme 1995-96; 97-98; 99-2002
Director Research Laboratory for Food Protein Production 1989-91
Director Food Research Centre 2007-present
Deputy Director Centre for Food and Drug Safety 2004-present



Grants obtained for teaching development, teaching-related awards, related publications, etc.


1. Case-based Learning of High School Science Subjects to Support Learning to Learn



2. A Science Enrichment Programme for Secondary 3-4 Students



3. Engaging Science Students in the Design and Enactment of Assessment



4. Promoting the Use of the Outcome-based Approach in Science Programmes:  Development of Learning Outcome Statements and Measurement Instruments






Special contributions:

  1. I have introduced the use of posters as an important student learning activity and continuous assessment in the course of BIOL2310 General and Molecular Genetics. This form of teaching activity has been adopted by other courses in Biology.
  2. I have organized a blog for teaching of the course FNSC4180 Food Microbiology in the past 4 years. All the important teaching materials, up-to-date information on food safety issues, etc can be effectively related to the students. This blog has been active even after the semester was over for the students to follow up on special foodborne disease cases such as the very important foodborne pathogen Escherichia coli outbreak in Germany. Daily information on the development of the outbreak is provided on the blog and the students can learn first-hand real-life outbreak investigation when they read the information on the blog. The links: Blogs are also constructed for several courses of mine, including LSCI5000-1, LSCI5004, BIOL1005, and FNSC5110.

I have been teaching enthusiastically for my whole career here in CUHK. I have introduced several teaching and assessment practices to the courses in Biology and Food and Nutritional Sciences. In my courses, I like to introduce the most recent concepts and information to the students. For undergraduate courses, I have established web-based learning, poster presentation, oral presentation, and knowledge about science in the real world. For project students, I have asked them to start real research as early as possible. I believe that to learn to practice science, students need to have hands-on experience early in their career. It is just like when we train a basketball player, we would want the player to play basketball early on rather than just learning all the regulations of basketball, reading about the game, understanding the theory behind the skills, and memorizing the stories of the great players. All these are important but one cannot become a great player by just doing these, one needs to practice and play real games. Over the years, I consider myself very fortunate and successful in training both undergraduate and postgraduate students to be good scientists. I graduated over 30 Master of Philosophy students, 15 PhD students, and numerous Master of Science and undergraduate project students. Most of the MPhil and PhD graduates from my laboratory excelled in science. Several have become faculty members or research scientists in very good universities or biotechnology companies. I have been very successful in obtaining research grants to support the research activities of the postgraduate and project students, and teaching grants, to support my developing and establishing new teaching pedagogical methods in the classes. All these have contributed to a very rewarding teaching portfolio in my professorial career in CUHK.





1. University Council Member 2004-2009

2. University Senate Member 1994-95; 1996-97;


3. Committee on Re-approval of Self-financed Taught Postgraduate Programmes Member 2012-present

4. Committee to Develop Policies Governing Self-Financed TPg Programmes Member 2013-present

5. Graduate Panel/Division of Life Sciences Head 2011-present

6. Food Research Centre Director 2007-present

7. University MPF Steering Committee Member 1999-2001

8. University Joint Consultative Committee Member 1997-2004

9. University Scholarship Committee Member 1998-2003

10. Assembly of Fellows, United College Fellow 1987-present

11. Science Faculty Board Executive Committee Member 2003-2009

12. Science Faculty Board Member/Chairman 1991-92;1995-97;


13. Science Faculty Scholarship Committee Chairman 1998-2003

14. Science Faculty Admission Committee Member 1994-95; 1996-97;


15. Appointments Committee, Science Faculty Member 1991-92

16. Biology Board of Studies Member 1984-2011

17. Biology Board of Studies Secretary 1994-1996

18. Food and Nutritional Sciences Programme Director 1994-95; 1996-97;

1998-99; 2003-2006

19. Food and Nutritional Sciences Programme Associate Director 1993-94; 1996-97;

1997-98; 99-2000

20. Molecular Biotechnology Programme Director 2000-2003

21. Molecular Biotechnology Programme Associate Director 1999-2000

22. School of Chinese Medicine, Board Member 1999-present

23. Management Committee of Technical Service Unit Representative 1994-97; 2003-2004

24. Graduate Panel/Graduate Division of Biology Head 1995-99

25. Graduate Panel/Graduate Division of Biology Member 1999-2006

26. Graduate Council Member 1994-2006; 2009-present

27. Graduate Council Executive Committee Member 1996-97; 2009-present

28. Biological Science Panel, Research Committee Member 1995-97; 1998-2004

29. Biology, United College Coordinator 1984-92

30. Biology Panel, Final Scholastic Assessment Convenor 1986-88

31. Biology Panel, Final Scholastic Assessment Member 1984-86

32. Management Committee, Biotechnology Lab Member 1986-2008

33. Research Laboratory for Food Science Director 1991-92; 1997-2000

34. Biology Department Executive Committee Member 1996-99

35. Biology Department Selection Committee Member 1993-present

36. Biology Department Curriculum Committee Member 1984-2006

37. Biology Department Staff-student Consultative Committee Member 1984-2004

38. Food and Nutritional Sciences Programme Executive Committee Chairman/member 1995-present

39. Molecular Biotechnology Programme Executive Committee Chairman/member 2000-2003

40. Food and Nutritional Sciences Programme Admission Committee Chairman/member 1993-present

41. Food and Nutritional Sciences Programme Staff-student consultative Committee Chairman/member 1993-present

42. United College Associate Head 2012- present

43. United College General Education Programme Dean 2012- present

44. United College Assembly of Fellows Fellow 1988-present

45. United College Disciplinary Committee Member 1996-present

46. United College Staff Housing Committee Member 1994-present

47. CUHK Campus (SARS) Task Force CUTA representative 2003-2004

48. CUHK Reference Group for Institutional Integration CUTA representative 2003-2004

49. CUHK Task Force to Advise on Institutional Integration CUTA representative 2002-03

50. CUHK Canteen Hygiene And Kitchen Safety Task Force Member 1997-98

51. Franklin Centre Amenity Management Committee Member 1995-97

52. Postgraduate Conference for Biological and Medical Science Students entitled: “Application of Novel Polymerase Chain Reaction DNA/RNA Fingerprinting Technology in Biological and Medical Research” Co-ordinator 1995


Other Services:

1. Teacher’s Association of CUHK (CUTA) Executive Committee Member 1995-96

2. Ditto Council Member 1995-present

3. Ditto Executive Committee Chairman 1997-99; 2001-2002

4. Ditto President 1999-2001; 2002-2004

5. World Society of Mushroom Biology and Mushroom Products Treasurer 1993-95

6. Hong Kong Society of Microbiology Secretary 1985-89

7. Joint University Biology Post-graduate Symposium Advisor 1997-99




Community Service on Government Boards and Committees


1. Committee on Reduction of Salt and Sugar in Food, Food and Health Bureau Member 2015-present

2. Chinese Medicines Board, Chinese Medicine Council of Hong Kong Member 2014-present

3. Hong Kong Chinese Medicine Development Committee Member 2013-present

4. Advisory Panel on the Second Food Consumption Survey, Centre for Food Safety Member 2013-present

5. Grant Review Board, Health and Medical Research Fund, Food and Health Bureau Member 2013-present

6. Hong Kong Council of Testing and Certification Member 2009-present

7. Scientific Committee on Enteric Infections and Foodborne Diseases, Centre for Health Protection, Department of Health Member 2004-present

8. Expert Committee on Food Safety, Environment and Food Bureau Chairman 2007-2012

9. Accreditation Advisory Board, Hong Kong Accreditation Services Chairman 2007-2012

10. Advisory Council on Food and Environmental Hygiene, Health, Welfare and Food Bureau Member 2000-2007

11. Biology and Medicine Panel, Research Grants Council, University Grants Committee Member 2001-2007

12. NSFC/RGC Joint Research Scheme Selection Committee, Research Grants Council, University Grants Committee Member 2001-2007

13. Election Committee for Legislative Council and Chief Executive Member 1998-2007

14. Election Committee for 10th and 11th National People’s Congress of People’s Republic of China Member 1998-2008

15. Steering Committee on Clean Hong Kong, Environment and Food Bureau Member 2000-2004

16. Publicity and Public Education Group on Clean Hong Kong, Environment and Food Bureau Member 2000-2004


Community Service on Voluntary Agencies, Trade, Community and Political Organizations


1. Expert Review Panel, Technology Committee of the Hong Kong R&D Centre for Logistics and Supply Chain Management Enabling Technologies Member 2015-2016

2. Technical Committee, Hong Kong Q-Mark Council Member 2012-present

3. Hong Kong Food & Science Technology Association Chief Expert Panel Leader 2012-present

4. Food Safety Technical Committee, Hong Kong Quality Assurance Agency Member 2009-present

5. Advisory Committee of Product Analysis Laboratory, Hong Kong Science and Technology Parks Corporation Member 2007-present

6. Sir Edward Youde Memorial Fellowships and Scholarships Selection Boards, Sir Edward Youde Memorial Fund Council, Hong Kong Member 1998-2004


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